This hotel in Thessaloniki is a part of the central downtown district. The Holiday Inn Thessaloniki is near the traditional market area, the Byzantine cathedral, and the Tsimiski shopping and entertainment street. The Holiday Inn Thessaloniki is 200 meters from the railway station and an equal distance from the ferry pick up points. It is a 30 minute journey to the international airport.

There are 177 rooms at the Holiday Inn Thessaloniki. Rooms have modern furnishings in earth tones, high speed Internet access, satellite television, mini bar, telephones, and en suite bathrooms. Pets are permitted but owners should call ahead for details.

The Holiday Inn Thessaloniki is a mid-range business and leisure property with three main areas. The hotel offers a full breakfast, and the house restaurants offer Grecian and Mediterranean dishes. There is a coffee shop and a cocktail lounge on the property, as well as a piano bar for evening entertainment. There are five conference rooms that can accommodate up to 600 people, supplemented by a modern business center. Parking is available.